Fig. 1 · Structure
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(Rac)-Tavapadon
Dopamine D1 Receptor Agonist
(Rac)-Tavapadon is a potent and selective non-catechol agonist of the dopamine D1 receptor. It demonstrates full agonism in the Gs activation assay (EC50 = 0.8 nM) and partial agonism in the β-arrestin2 recruitment assay (EC50 = 68 nM). This compound exhibits significant antiparkinsonian activity, making it valuable for research into neurodegenerative diseases and dopamine signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 1643462-64-9 |
| Applications | Dopamine D1 Receptor Agonist |
| Formula | C19H16F3N3O3 |
| Molecular Weight | 391.34 |
| Synonyms | (Rac)-PF-06649751; (Rac)-CVL-751 |
| SMILES | O=C1NC(C(C)=C(C2=CC=C(OC3=NC=CC=C3C(F)(F)F)C=C2C)N1C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.