Fig. 1 · Structure
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Ranakinin
NK1R Agonist
Ranakinin is a potent NK1R agonist that selectively activates neurokinin-1 receptors. It inhibits the binding of selective NK1 radioligands, leading to the activation of phospholipase C and subsequent enhancement of polyphosphoinositide hydrolysis. This compound stimulates inositol phosphate production while decreasing membrane polyphosphoinositide levels, and it also promotes the secretion of corticosterone and aldosterone. Ranakinin is valuable for research applications related to neurobiology and endocrine signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 139446-71-2 |
| Applications | NK1R Agonist |
| Formula | C62H95N17O15S |
| Molecular Weight | 1350.59 |
| SMILES | C([C@@H](NC(=O)[C@H]1N(C([C@H](CCCCN)N)=O)CCC1)CC(N)=O)(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC4=CC=C(O)C=C4)C(NCC(N[C@H](C(N[C@@H](CCSC)C(N)=O)=O)CC(C)C)=O)=O)=O)=O)CCCNC(=N)N)=O)CCC(O)=O)=O)CCC2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.