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Ranakinin

Catalog No.: A62023
NK1R Agonist
Ranakinin is a potent NK1R agonist that selectively activates neurokinin-1 receptors. It inhibits the binding of selective NK1 radioligands, leading to the activation of phospholipase C and subsequent enhancement of polyphosphoinositide hydrolysis. This compound stimulates inositol phosphate production while decreasing membrane polyphosphoinositide levels, and it also promotes the secretion of corticosterone and aldosterone. Ranakinin is valuable for research applications related to neurobiology and endocrine signaling.
Ranakinin 139446-71-2 NK1R Agonist
Grouped product items
Size Price Stock Qty
25mg
$2,535.00
In stock
50mg
$3,265.00
In stock
100mg
$4,400.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionRanakinin is a potent NK1R agonist that selectively activates neurokinin-1 receptors. It inhibits the binding of selective NK1 radioligands, leading to the activation of phospholipase C and subsequent enhancement of polyphosphoinositide hydrolysis. This compound stimulates inositol phosphate production while decreasing membrane polyphosphoinositide levels, and it also promotes the secretion of corticosterone and aldosterone. Ranakinin is valuable for research applications related to neurobiology and endocrine signaling.
Product Information
Catalog NumA62023
FormulaC62H95N17O15S
Molecular Weight1350.59
CAS Number139446-71-2
SequenceLys-Pro-Asn-Pro-Glu-Arg-Phe-Tyr-Gly-Leu-Met-NH2
Sequence shorteningKPNPERFYGLM-NH2
SMILESC([C@@H](NC(=O)[C@H]1N(C([C@H](CCCCN)N)=O)CCC1)CC(N)=O)(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC4=CC=C(O)C=C4)C(NCC(N[C@H](C(N[C@@H](CCSC)C(N)=O)=O)CC(C)C)=O)=O)=O)=O)CCCNC(=N)N)=O)CCC(O)=O)=O)CCC2
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GPCR/G Protein > Neurokinin Receptors