Fig. 1 · Structure
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Raseglurant
mGlu5 Receptor NEM
Raseglurant (ADX-10059) is a negative allosteric modulator of the mGlu5 receptor, demonstrating potential therapeutic effects in migraine management. This compound has been shown to alleviate Haloperidol-induced catalepsy in murine models, indicating its utility in studying disorders related to dopaminergic signaling. Raseglurant can be employed in research focused on the modulation of mGlu5 receptor activity and its implications in neurological diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 757950-09-7 |
| Applications | mGlu5 Receptor NEM |
| Formula | C15H13FN2 |
| Molecular Weight | 240.28 |
| Synonyms | ADX-10059 |
| SMILES | NC1=C(C)C=C(C)N=C1C#CC2=CC=CC(F)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.