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Form	MW
Razuprotafib sodium This page	608.68
Razuprotafib	586.70

Razuprotafib sodium

VE-PTP Inhibitor

Razuprotafib sodium is a highly selective inhibitor of vascular endothelial protein tyrosine phosphatase (VE-PTP) with an IC50 of 17 pM. It enhances TIE2 receptor activation and promotes ANG1-induced signaling, stimulating the phosphorylation of key pathway molecules such as AKT, eNOS, and ERK. Additionally, Razuprotafib sodium exhibits moderate inhibition of the related phosphatase PTP1B with an IC50 of 780 nM, demonstrating exceptional selectivity for VE-PTP compared to various other phosphatases, aside from HPTPη and HPTPγ. This compound holds relevance for research areas involving vascular biology and angiogenesis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1809275-69-1
Applications	VE-PTP Inhibitor
Formula	C₂₆H₂₅N₄NaO₆S₃
Molecular Weight	608.68
Synonyms	AKB-9778 sodium
SMILES	O=S(NC(C=C1)=CC=C1C[C@@H](C2=CSC(C3=CC=CS3)=N2)NC([C@@H](NC(OC)=O)CC4=CC=CC=C4)=O)(O[Na])=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.