Fig. 1 · Structure
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Razuprotafib
VE-PTP Inhibitor
Razuprotafib is a potent and selective inhibitor of vascular endothelial protein tyrosine phosphatase (VE-PTP), exhibiting an IC50 of 17 pM. This compound facilitates TIE2 activation and enhances ANG1-induced TIE2 signaling, leading to the phosphorylation of key downstream molecules, including AKT, eNOS, and ERK. Razuprotafib also demonstrates moderate inhibition of the related phosphatase PTP1B with an IC50 of 780 nM, while maintaining high selectivity for VE-PTP against various phosphatases, apart from HPTPη and HPTPγ. This makes it a valuable tool for research in vascular biology and angiogenesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1008510-37-9 |
| Applications | VE-PTP Inhibitor |
| Formula | C26H26N4O6S3 |
| Molecular Weight | 586.70 |
| Synonyms | AKB-9778 |
| SMILES | O=C([C@@H](NC(OC)=O)CC1=CC=CC=C1)N[C@H](C2=CSC(C3=CC=CS3)=N2)CC4=CC=C(NS(=O)(O)=O)C=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.