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RdRP-IN-9

RdRp Inhibitor

RdRP-IN-9 is a reversible covalent allosteric inhibitor targeting RNA-dependent RNA polymerase (RdRp). This compound exhibits significant anti-coronavirus activity, with an EC50 value of 0.68 μM against HCoV-OC43. RdRP-IN-9 acts by reversibly acylating Cys12 in the NiRAN domain of non-structural protein 12 (nsp 12), resulting in a sustained antiviral effect. Additionally, it shows synergistic activity when used in combination with other antiviral agents such as Molnupiravir, making it a valuable tool for research in therapeutic strategies against coronavirus infections.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1101848-34-3
Applications	RdRp Inhibitor
Formula	C₁₉H₂₁NO₅
Molecular Weight	343.37
SMILES	[H][C@@]12[C@](C3=C[C@H](O)[C@H]2OC(CC)=O)([H])N(CC3)CC4=CC5=C(OCO5)C=C41

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.