Repinotan hydrochloride is a potent and selective agonist of the 5-HT1A receptor, demonstrating strong brain penetration and oral bioavailability. With Ki values of 0.19 nM in calf hippocampus, 0.25 nM in rat and human cortex, and 0.59 nM in rat hippocampus, it exhibits a high affinity for its primary target while showing minimal interaction with other related receptors. This compound is known for its pronounced neuroprotective effects and is valuable in research applications related to neurological disorders and serotonergic signaling pathways.
Repinotan hydrochloride is a potent and selective agonist of the 5-HT1A receptor, demonstrating strong brain penetration and oral bioavailability. With Ki values of 0.19 nM in calf hippocampus, 0.25 nM in rat and human cortex, and 0.59 nM in rat hippocampus, it exhibits a high affinity for its primary target while showing minimal interaction with other related receptors. This compound is known for its pronounced neuroprotective effects and is valuable in research applications related to neurological disorders and serotonergic signaling pathways.
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