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Rhetsinine

Aldose Reductase Inhibitor

Rhetsinine is an inhibitor of aldose reductase, isolated from the plant Evodia rutaecarpa. Demonstrating an IC50 value of 24.1 μM, rhetsinine effectively reduces sorbitol accumulation by 79.3% at a concentration of 100 μM. This compound offers significant potential for investigations into diabetic complications, such as diabetic neuropathy and retinopathy, providing a valuable tool for research focused on managing and understanding diabetes-related disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	526-43-2
Applications	Aldose Reductase Inhibitor
Formula	C₁₉H₁₇N₃O₂
Molecular Weight	319.36
SMILES	O=C(N1C(C2=C(CC1)C3=C(C=CC=C3)N2)=O)C4=C(NC)C=CC=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.