RIPK1-IN-11 is a potent and orally active inhibitor of receptor-interacting protein kinase 1 (RIPK1), demonstrating a Kd of 9.2 nM and an IC50 of 67 nM. This compound effectively inhibits necroptosis in human and mouse cells, with an EC50 range of 17-30 nM. Due to its anti-inflammatory properties, RIPK1-IN-11 is valuable in researching the pathophysiology of inflammatory diseases and cell death mechanisms.
RIPK1-IN-11 is a potent and orally active inhibitor of receptor-interacting protein kinase 1 (RIPK1), demonstrating a Kd of 9.2 nM and an IC50 of 67 nM. This compound effectively inhibits necroptosis in human and mouse cells, with an EC50 range of 17-30 nM. Due to its anti-inflammatory properties, RIPK1-IN-11 is valuable in researching the pathophysiology of inflammatory diseases and cell death mechanisms.
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