RIPK1-IN-21

Catalog No.: A25233
RIPK1 Inhibitor
RIPK1-IN-21 is a selective inhibitor of receptor-interacting protein kinase 1 (RIPK1), exhibiting an EC50 value of 14.8 nM. This compound is valuable for research into neurodegenerative, autoimmune, and inflammatory diseases, where modulation of RIPK1 activity may play a critical role. Its potent inhibitory effects enable investigations into the mechanisms of RIPK1-mediated cell death and inflammation.
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5mg
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50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionRIPK1-IN-21 is a selective inhibitor of receptor-interacting protein kinase 1 (RIPK1), exhibiting an EC50 value of 14.8 nM. This compound is valuable for research into neurodegenerative, autoimmune, and inflammatory diseases, where modulation of RIPK1 activity may play a critical role. Its potent inhibitory effects enable investigations into the mechanisms of RIPK1-mediated cell death and inflammation.
Product Information
Catalog NumA25233
FormulaC17H14F2N4O
Molecular Weight328.32
CAS Number3016304-64-3
SMILESO=C1N(C2(C3)CC3(C#N)C2)N=C4N1[C@@H](CC4)C5=CC(F)=CC(F)=C5
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