RIPK1-IN-23

Catalog No.: A25222
RIPK1 Inhibitor
RIPK1-IN-23 is a selective inhibitor of Receptor Interacting Protein Kinase 1 (RIPK1), exhibiting potent anti-necroptotic effects with an EC50 of 1.7 nM in HT-29 cells. This compound also demonstrates significant anti-inflammatory activity, making it a valuable tool for investigating necroptosis and its associated inflammatory pathways in various biological research applications.
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5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionRIPK1-IN-23 is a selective inhibitor of Receptor Interacting Protein Kinase 1 (RIPK1), exhibiting potent anti-necroptotic effects with an EC50 of 1.7 nM in HT-29 cells. This compound also demonstrates significant anti-inflammatory activity, making it a valuable tool for investigating necroptosis and its associated inflammatory pathways in various biological research applications.
Product Information
Catalog NumA25222
FormulaC27H22N6O3
Molecular Weight478.50
CAS Number3031534-16-1
SMILESCN1C([C@H](COC2=CC=C(C=C21)C3=CC=C(C=C3)C#N)NC(C4=NNC(CC5=CC=CC=C5)=N4)=O)=O
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