RIPK1-IN-35 is a selective and orally bioavailable inhibitor of receptor-interacting protein kinase 1 (RIPK1) with an IC50 of 5.33 nM. This compound exhibits a strong protective effect against necroptosis in both human and murine cell models. It demonstrates significant therapeutic potential in experimental models of TNF-α-induced systemic inflammatory response syndrome and DSS-induced inflammatory bowel disease. RIPK1-IN-35 is valuable for research into inflammatory diseases associated with necroptosis.
RIPK1-IN-35 is a selective and orally bioavailable inhibitor of receptor-interacting protein kinase 1 (RIPK1) with an IC50 of 5.33 nM. This compound exhibits a strong protective effect against necroptosis in both human and murine cell models. It demonstrates significant therapeutic potential in experimental models of TNF-α-induced systemic inflammatory response syndrome and DSS-induced inflammatory bowel disease. RIPK1-IN-35 is valuable for research into inflammatory diseases associated with necroptosis.
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