RIPK2/3-IN-2 is a potent dual inhibitor of receptor-interacting protein kinases 2 and 3 (RIPK2 and RIPK3), exhibiting IC50 values of 12 nM and 18 nM, respectively. This compound effectively induces necroptosis, showcasing an EC50 value of 0.16 μM. RIPK2/3-IN-2 can be utilized in research exploring programmed cell death mechanisms and the role of necroptosis in various pathological conditions.
RIPK2/3-IN-2 is a potent dual inhibitor of receptor-interacting protein kinases 2 and 3 (RIPK2 and RIPK3), exhibiting IC50 values of 12 nM and 18 nM, respectively. This compound effectively induces necroptosis, showcasing an EC50 value of 0.16 μM. RIPK2/3-IN-2 can be utilized in research exploring programmed cell death mechanisms and the role of necroptosis in various pathological conditions.
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