RIPK2-IN-5 is a high-affinity inhibitor of receptor-interacting protein kinase 2 (RIPK2), demonstrating an IC50 value of 5.1 nM. This compound exhibits significant anti-inflammatory effects by reducing the secretion of TNF-α in response to MDP in a dose-dependent manner. With moderate stability in human liver microsomes, RIPK2-IN-5 serves as a valuable tool for investigating immune diseases and related therapeutic strategies.
RIPK2-IN-5 is a high-affinity inhibitor of receptor-interacting protein kinase 2 (RIPK2), demonstrating an IC50 value of 5.1 nM. This compound exhibits significant anti-inflammatory effects by reducing the secretion of TNF-α in response to MDP in a dose-dependent manner. With moderate stability in human liver microsomes, RIPK2-IN-5 serves as a valuable tool for investigating immune diseases and related therapeutic strategies.
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