Fig. 1 · Structure
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RK-682
PTPase Inhibitor
RK-682 is a potent inhibitor of protein tyrosine phosphatases (PTPases), targeting specifically the dephosphorylation of CD45 and VHR, with IC50 values of 54 μM and 2.0 μM, respectively. This inhibition disrupts the ERK signaling pathway, leading to significant effects on cancer cell viability with IC50 values of 78.2 nM for MGH-U3, 43.2 nM for T24, and 145 nM for UROtsa. Additionally, RK-682 induces cell cycle arrest at the G1/S phase and suppresses both cell migration and autophagy in MGH-U3 and T24 cell lines, making it a valuable tool for cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 150627-37-5 |
| Applications | PTPase Inhibitor |
| Formula | C21H36O5 |
| Molecular Weight | 368.51 |
| SMILES | CCCCCCCCCCCCCCCC(C1=C([C@@H](CO)OC1=O)O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.