Fig. 1 · Structure
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RMC-3943
SHP2 Inhibitor
RMC-3943 is an allosteric inhibitor of SHP2, demonstrating a potent inhibition of full-length SHP2 in biochemical assays with an IC50 of 2.19 nM. This compound is valuable for research into the modulation of SHP2 activity, which is implicated in various signaling pathways and disease states, including cancer. RMC-3943 can aid in elucidating the role of SHP2 in cellular processes and may contribute to the development of targeted therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1801764-60-2 |
| Applications | SHP2 Inhibitor |
| Formula | C18H22Cl2N6S |
| Molecular Weight | 425.38 |
| SMILES | N[C@H]1C2(CCC1)CCN(C3=NC(N)=C(N=C3)SC4=CC=NC(Cl)=C4Cl)CC2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.