Fig. 1 · Structure
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RN-9893 hydrochloride
Cat. No.
A68812
CAS
2109450-40-8
TRPV4 Antagonist
RN-9893 hydrochloride is a potent antagonist of the transient receptor potential vanilloid 4 (TRPV4) channel, exhibiting IC50 values of 0.42 μM for human and 0.66 μM for rat TRPV4. This compound is valuable for research focused on TRPV4-related physiological processes and pathologies, including pain sensation and inflammatory responses. Its oral bioactivity makes it suitable for in vivo studies investigating the role of TRPV4 in various biological systems.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 2109450-40-8 |
| Applications | TRPV4 Antagonist |
| Formula | C21H24ClF3N4O5S |
| Molecular Weight | 536.95 |
| SMILES | O=S(C(C=C1)=CC=C1NC(C2=C([N+]([O-])=O)C=C(C(F)(F)F)C=C2)=O)(N3CCN(C(C)C)CC3)=O.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.