Fig. 1 · Structure
Documents & Downloads
RN-9893
Cat. No.
A68740
CAS
1803003-68-0
TRPV4 Receptor Antagonist
RN-9893 is a potent and selective antagonist of the TRPV4 receptor, exhibiting IC50 values of 320 nM, 420 nM, and 660 nM for mouse, human, and rat channels, respectively. This compound is valuable for research applications involving the modulation of TRPV4-mediated physiological processes. Its selective inhibition can aid in studies related to pain sensation, inflammation, and other TRPV4-associated diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1803003-68-0 |
| Applications | TRPV4 Receptor Antagonist |
| Formula | C21H23F3N4O5S |
| Molecular Weight | 500.49 |
| SMILES | O=S(C(C=C1)=CC=C1NC(C2=C([N+]([O-])=O)C=C(C(F)(F)F)C=C2)=O)(N3CCN(C(C)C)CC3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.