Fig. 1 · Structure

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Ro 20-0657/000

Dihydrofolate Reductase Inhibitor

Ro 20-0657/000 is a dihydrofolate reductase inhibitor that serves as a metabolite of trimethoprim. This compound exhibits antibacterial activity, making it relevant for both human and veterinary medical applications. Ro 20-0657/000 is utilized in research to investigate the mechanisms of folate metabolism and the potential therapeutic effects of dihydrofolate reductase inhibition.

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 29606-06-2
Applications Dihydrofolate Reductase Inhibitor
Formula C14H18N4O4
Molecular Weight 306.32
SMILES
OC(C1=CC(OC)=C(OC)C(OC)=C1)C2=CN=C(N)N=C2N

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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