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RO-28-2653

MMP Inhibitor

RO-28-2653 is an orally active inhibitor of matrix metalloproteinases (MMPs), specifically targeting MMP2, MMP9, and membrane-type 1-MMP. This compound exhibits selective inhibitory effects, potentially reducing side effects associated with broad-spectrum MMP inhibitors, such as musculoskeletal pain. In preclinical studies, RO-28-2653 has demonstrated significant tumor growth inhibition in rat models of prostate cancer, making it a valuable tool for research on hormone-sensitive tumors and related therapeutic applications.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	261956-22-3
Applications	MMP Inhibitor
Formula	C₂₆H₂₃N₅O₅
Molecular Weight	485.49
SMILES	O=C1NC(C(N2CCN(C3=CC=C([N+]([O-])=O)C=C3)CC2)(C4=CC=C(C5=CC=CC=C5)C=C4)C(N1)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.