Fig. 1 · Structure
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RO2959 monohydrochloride
CRAC Channel Inhibitor
RO2959 monohydrochloride is a selective CRAC channel inhibitor that primarily targets Orai1/Stim1 channels, demonstrating an IC50 of 25 nM for blocking store-operated calcium entry (SOCE). This compound effectively inhibits human interleukin-2 (IL-2) production and disrupts T cell receptor-mediated gene expression and functional pathways. RO2959 monohydrochloride is a valuable tool for studying calcium signaling in immune responses and may have applications in immunotherapy research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2309172-44-7 |
| Applications | CRAC Channel Inhibitor |
| Formula | C21H20ClF2N5OS |
| Molecular Weight | 463.93 |
| SMILES | O=C(NC1=NC=C(C2=C(C)CCN(C3=NC=C(C)S3)C2)N=C1)C4=C(F)C=CC=C4F.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.