RO5101576 is a potent antagonist of the leukotriene B4 (LTB4) receptor, effectively inhibiting LTB4-induced calcium mobilization and chemotaxis in human neutrophils. This compound demonstrates significant reduction of LTB4-induced pulmonary eosinophilia in guinea pigs, and it inhibits allergen- and ozone-induced pulmonary neutrophilia in nonhuman primates with efficacy similar to that of budesonide. Notably, RO5101576 does not affect LPS-induced neutrophilia in guinea pigs or cigarette smoke-induced neutrophilia in mice and rats. Its favorable performance in toxicology studies indicates good tolerability.
RO5101576 is a potent antagonist of the leukotriene B4 (LTB4) receptor, effectively inhibiting LTB4-induced calcium mobilization and chemotaxis in human neutrophils. This compound demonstrates significant reduction of LTB4-induced pulmonary eosinophilia in guinea pigs, and it inhibits allergen- and ozone-induced pulmonary neutrophilia in nonhuman primates with efficacy similar to that of budesonide. Notably, RO5101576 does not affect LPS-induced neutrophilia in guinea pigs or cigarette smoke-induced neutrophilia in mice and rats. Its favorable performance in toxicology studies indicates good tolerability.
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