Fig. 1 · Structure
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RO5101576
Cat. No.
A73408
CAS
1123155-95-2
Endogenous Metabolite
RO5101576 is a potent antagonist of the leukotriene B4 (LTB4) receptor, effectively inhibiting LTB4-induced calcium mobilization and chemotaxis in human neutrophils. This compound demonstrates significant reduction of LTB4-induced pulmonary eosinophilia in guinea pigs, and it inhibits allergen- and ozone-induced pulmonary neutrophilia in nonhuman primates with efficacy similar to that of budesonide. Notably, RO5101576 does not affect LPS-induced neutrophilia in guinea pigs or cigarette smoke-induced neutrophilia in mice and rats. Its favorable performance in toxicology studies indicates good tolerability.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1123155-95-2 |
| Applications | Endogenous Metabolite |
| Formula | C36H38O8S |
| Molecular Weight | 630.75 |
| SMILES | O=C(CCCOC1=CC=CC(CCCCCCOC2=CC(C3=CSC=C3)=CC(C4=CC=C5OCOC5=C4)=C2)=C1CCC(O)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.