RO5527239

Catalog No.: A60411
TGR5 Agonist
RO5527239 is an orally active agonist of the TGR5 receptor, which stimulates enteroendocrine L cells to increase the secretion of the endogenous hormone GLP-2. This compound demonstrates potential in modulating gastrointestinal functions and may aid in research surrounding metabolic disorders. Its activation of TGR5 highlights its significance in studies focused on energy homeostasis and gut hormone dynamics.
Grouped product items
Size Price Stock Qty
25mg
$1,655.00
In stock
50mg
$2,115.00
In stock
100mg
$2,720.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionRO5527239 is an orally active agonist of the TGR5 receptor, which stimulates enteroendocrine L cells to increase the secretion of the endogenous hormone GLP-2. This compound demonstrates potential in modulating gastrointestinal functions and may aid in research surrounding metabolic disorders. Its activation of TGR5 highlights its significance in studies focused on energy homeostasis and gut hormone dynamics.
Product Information
Catalog NumA60411
FormulaC28H31N3O3
Molecular Weight457.56
CAS Number1354812-99-9
SMILESO=C(C1CCN(C2=CC=C([C@H](C3=CC=CC=C3C)C/C(C4=CC(C)=NC=C4)=N\O)C=C2)CC1)O
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