Rofecoxib-d5 is a deuterium-labeled derivative of Rofecoxib, a potent and selective inhibitor of cyclooxygenase-2 (COX-2). This compound exhibits inhibitory activity with IC50 values of 26 nM in human osteosarcoma cells and 18 nM in Chinese hamster ovary cells, demonstrating over 1000-fold selectivity for COX-2 compared to COX-1. Rofecoxib-d5 is suitable for use in pharmacokinetic studies, metabolic labeling, and other research applications involving COX-2 inhibition.
Rofecoxib-d5 is a deuterium-labeled derivative of Rofecoxib, a potent and selective inhibitor of cyclooxygenase-2 (COX-2). This compound exhibits inhibitory activity with IC50 values of 26 nM in human osteosarcoma cells and 18 nM in Chinese hamster ovary cells, demonstrating over 1000-fold selectivity for COX-2 compared to COX-1. Rofecoxib-d5 is suitable for use in pharmacokinetic studies, metabolic labeling, and other research applications involving COX-2 inhibition.
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