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RORγ antagonist 1

Name: RORγ antagonist 1
Brand: Adooq Bioscience
SKU: A77590
Availability: OutOfStock

Cat. No. A77590 CAS 3049676-15-2

RORγ antagonist

RORγ antagonist 1 is a potent antagonist of the retinoic acid receptor-related orphan receptor gamma (RORγ) with a dissociation constant (KD) of 0.18 μM. This compound demonstrates significant anti-proliferative effects in HPAF-II pancreatic cancer xenograft models. Additionally, RORγ antagonist 1 inhibits key signaling pathways, including RAS/MAPK and AKT/mTORC1, and induces caspase-dependent apoptosis in pancreatic cancer cells, making it a valuable tool for cancer research and potential therapeutic applications.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	3049676-15-2
Applications	RORγ antagonist
Formula	C₃₅H₆₀N₂O₂
Molecular Weight	540.86
SMILES	O[C@H]1CC[C@@]2(C)[C@](CC[C@]3(C)[C@]2([H])CC[C@@]4([H])[C@@]3(C)CC[C@]5(C(NCCCN(C)C)=O)[C@]4([H])[C@H](C(C)=C)CC5)([H])C1(C)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.