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RORγ inverse agonist 2

Catalog No.: A77596
RORγ Inverse Agonist
RORγ inverse agonist 2 is a potent inverse agonist targeting the retinoic acid receptor-related orphan receptor RORγ, exhibiting IC50 values of 0.4 μM and 0.9 μM for Gal4-RORγ and full-length RORγ, respectively. This compound is significant for research applications focused on autoimmune diseases, providing insights into RORγ's role in immune regulation and pathology.
RORγ inverse agonist 2 1242610-59-8 RORγ Inverse Agonist
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionRORγ inverse agonist 2 is a potent inverse agonist targeting the retinoic acid receptor-related orphan receptor RORγ, exhibiting IC50 values of 0.4 μM and 0.9 μM for Gal4-RORγ and full-length RORγ, respectively. This compound is significant for research applications focused on autoimmune diseases, providing insights into RORγ's role in immune regulation and pathology.
Product Information
Catalog NumA77596
FormulaC35H48O4
Molecular Weight532.75
CAS Number1242610-59-8
SMILESCC1(C)C(/C(C[C@]2(C)[C@@]3([H])CC[C@]4([H])[C@@]5([H])[C@H](C(C)=C)CC[C@@](C(O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H])=C\C6=CC=CO6)=O
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Endocrinology-Hormones > ROR