Fig. 1 · Structure
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RORγt agonist 1
Cat. No.
A77578
CAS
2377378-89-5
ROR Agonist
RORγt agonist 1 is a potent agonist of the RORγt receptor, demonstrating an EC50 of 20.8 nM. This compound exhibits high metabolic stability, enhanced aqueous solubility, and favorable pharmacokinetics in murine models. RORγt agonist 1 is a promising candidate for cancer immunotherapy research applications, targeting immune modulation pathways to aid in therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 2377378-89-5 |
| Applications | ROR Agonist |
| Formula | C24H17F6NO5S |
| Molecular Weight | 545.45 |
| SMILES | FC1=CC(OC(F)F)=CC(C2=CC=C(CC(CC(O)=O)N3S(C4=CC(C(F)(F)F)=CC=C4)(=O)=O)C3=C2)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.