RORγt Inverse Agonist 10 is a potent inverse agonist targeting the retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt), with an IC50 of 51 nM. This compound effectively suppresses the expression of key genes involved in the pathogenesis of psoriasis, including IL-17A, IL-22, and IL-23R. It is suitable for research applications exploring the mechanisms of autoimmune diseases and the development of novel therapeutics for psoriasis.
RORγt Inverse Agonist 10 is a potent inverse agonist targeting the retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt), with an IC50 of 51 nM. This compound effectively suppresses the expression of key genes involved in the pathogenesis of psoriasis, including IL-17A, IL-22, and IL-23R. It is suitable for research applications exploring the mechanisms of autoimmune diseases and the development of novel therapeutics for psoriasis.
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