Fig. 1 · Structure
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RORγt inverse agonist 13
Cat. No.
A77563
CAS
2170477-75-3
RORγt Inverse Agonist
RORγt inverse agonist 13 is a selective inverse agonist targeting the RORγt receptor with an IC50 of 63.8 nM. This compound demonstrates potent biological activity, making it suitable for research applications focusing on autoimmune diseases and T cell differentiation. Its improved agent-like properties enhance its utility in preclinical studies investigating the modulation of RORγt signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inverse Agonist |
| CAS Number | 2170477-75-3 |
| Applications | RORγt Inverse Agonist |
| Formula | C23H17Cl2F3N2O4 |
| Molecular Weight | 513.29 |
| SMILES | O=C(O)CC1=CC=C(CNC(NC2=CC(Cl)=C(C3=CC=CC=C3OC(F)(F)F)C(Cl)=C2)=O)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.