Fig. 1 · Structure
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RORγt inverse agonist 14
Cat. No.
A77581
CAS
2672496-70-5
RORγt Inverse Agonist
RORγt inverse agonist 14 is a selective inverse agonist targeting the retinoic acid receptor-related orphan receptor gamma t (RORγt) with an EC50 of 2.5 nM. This compound exhibits significant anti-inflammatory properties, making it suitable for research into autoimmune conditions such as rheumatoid arthritis and psoriasis. Its oral bioavailability facilitates in vivo studies, contributing valuable insights into RORγt modulation in therapeutic contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inverse Agonist |
| CAS Number | 2672496-70-5 |
| Applications | RORγt Inverse Agonist |
| Formula | C26H26F8N2O6S2 |
| Molecular Weight | 678.61 |
| SMILES | O=C(N[C@@H]1CC[C@@]2(S(=O)(C3=CC=C(F)C=C3)=O)C4=C(N=C(C(C(F)(F)F)(F)C(F)(F)F)C=C4)CC[C@]21[H])[C@](C)(O)CS(=O)(C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.