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RORγt Inverse agonist 6

Catalog No.: A77582
RORγt Inverse Agonist
RORγt Inverse Agonist 6 is designed to inhibit the RORγt receptor, a key regulator in Th17-driven autoimmune diseases. This compound effectively suppresses IL-17A gene expression following IL-23 stimulation in vivo, making it a valuable tool for exploring therapeutic strategies against inflammatory conditions. Its application is essential for researchers investigating the role of Th17 cells in various autoimmune disorders.
RORγt Inverse agonist 6 1887161-80-9 RORγt Inverse Agonist
Grouped product items
Size Price Stock Qty
1mg
$45.00
In stock
5mg
$115.00
In stock
10mg
$180.00
In stock
25mg
$285.00
In stock
50mg
$380.00
In stock
100mg
$475.00
In stock
200mg
$610.00
In stock
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Research use only. We do not sell to patients.
Data Sheet SDS

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionRORγt Inverse Agonist 6 is designed to inhibit the RORγt receptor, a key regulator in Th17-driven autoimmune diseases. This compound effectively suppresses IL-17A gene expression following IL-23 stimulation in vivo, making it a valuable tool for exploring therapeutic strategies against inflammatory conditions. Its application is essential for researchers investigating the role of Th17 cells in various autoimmune disorders.
Product Information
Catalog NumA77582
FormulaC28H29ClN6O5
Molecular Weight565.02
CAS Number1887161-80-9
SMILESO=C([C@H]1CN(C(NC2=CC3=C(N(C(C)C)C(N(CC4CC4)C3=O)=O)C=C2)=O)CCO1)NC5=CC=C(C#N)C(Cl)=C5
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Endocrinology-Hormones > ROR