Fig. 1 · Structure
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RORγt Inverse agonist 8
Cat. No.
A77588
CAS
2079892-79-6
RORγt Inverse Agonist
RORγt Inverse Agonist 8 acts as a selective inverse agonist targeting the retinoic acid receptor-related orphan receptor gamma t (RORγt). With an IC50 of 19 nM for the human RORγt ligand-binding domain, this compound demonstrates significant potential in modulating RORγt activity. Its biological activity is relevant for research in autoimmune diseases and T helper 17 (Th17) cell differentiation, providing a valuable tool for investigators studying immune response pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inverse Agonist |
| CAS Number | 2079892-79-6 |
| Applications | RORγt Inverse Agonist |
| Formula | C26H33N7O2 |
| Molecular Weight | 475.59 |
| SMILES | O=C(C1=CN=C(C)N=C1)NC2=CN3C(C(CN4C[C@H](C)N(C(C5CCCC5)=O)CC4)=C2C)=NC=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.