RORγt Inverse Agonist 8 acts as a selective inverse agonist targeting the retinoic acid receptor-related orphan receptor gamma t (RORγt). With an IC50 of 19 nM for the human RORγt ligand-binding domain, this compound demonstrates significant potential in modulating RORγt activity. Its biological activity is relevant for research in autoimmune diseases and T helper 17 (Th17) cell differentiation, providing a valuable tool for investigators studying immune response pathways.
RORγt Inverse Agonist 8 acts as a selective inverse agonist targeting the retinoic acid receptor-related orphan receptor gamma t (RORγt). With an IC50 of 19 nM for the human RORγt ligand-binding domain, this compound demonstrates significant potential in modulating RORγt activity. Its biological activity is relevant for research in autoimmune diseases and T helper 17 (Th17) cell differentiation, providing a valuable tool for investigators studying immune response pathways.
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