Rotigaptide (ZP123) is a novel and specific modulator of connexin 43 (Cx43) that prevents the uncoupling of Cx43-mediated gap junction communication and restores intercellular connectivity under acute metabolic stress. As a potent and stable antiarrhythmic peptide (AAP), Rotigaptide shows strong potential for the investigation of cardiac arrhythmias, particularly atrial fibrillation.
Rotigaptide (ZP123) is a novel and specific modulator of connexin 43 (Cx43) that prevents the uncoupling of Cx43-mediated gap junction communication and restores intercellular connectivity under acute metabolic stress. As a potent and stable antiarrhythmic peptide (AAP), Rotigaptide shows strong potential for the investigation of cardiac arrhythmias, particularly atrial fibrillation.
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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