Fig. 1 · Structure
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Roxindole hydrochloride
Dopamine Autoreceptors Agonist
Roxindole hydrochloride is a potent agonist of dopamine autoreceptors, primarily targeting the D2-like subtype with low nanomolar affinity. This compound exhibits significant antipsychotic and antidepressant properties, making it valuable in the research of both positive and negative symptoms of schizophrenia. Additionally, Roxindole acts as a 5-HT1A agonist and a 5-HT uptake inhibitor, demonstrating high affinity for the 5-HT1A receptor (IC50=0.9 nM), contributing to its multifaceted therapeutic potential.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 108050-82-4 |
| Applications | Dopamine Autoreceptors Agonist |
| Formula | C23H27ClN2O |
| Molecular Weight | 382.93 |
| Synonyms | EMD 38362 |
| SMILES | OC1=CC2=C(C=C1)NC=C2CCCCN3CCC(C4=CC=CC=C4)=CC3.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.