Fig. 1 · Structure
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Roxindole
Dopamine Autoreceptors Agonist
Roxindole is a potent agonist of dopamine autoreceptors, specifically targeting the D2-like subtype with low nanomolar affinity. This compound exhibits significant biological activity relevant to the study of both positive and negative symptoms associated with schizophrenia. Additionally, Roxindole functions as a 5-HT1A agonist and a serotonin uptake inhibitor, highlighting its potential utility in antipsychotic and antidepressant research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 112192-04-8 |
| Applications | Dopamine Autoreceptors Agonist |
| Formula | C23H26N2O |
| Molecular Weight | 346.47 |
| Synonyms | EMD 49980 |
| SMILES | OC1=CC2=C(C=C1)NC=C2CCCCN3CCC(C4=CC=CC=C4)=CC3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.