Fig. 1 · Structure
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RP-2119
Polθ Inhibitor
RP-2119 is an orally active inhibitor of Polymerase Theta (Polθ), which plays a critical role in DNA repair mechanisms. This compound exhibits notable antitumor activity, making it a valuable tool in cancer research and therapeutic development. RP-2119 is particularly relevant for studies focusing on DNA damage response and repair pathways in oncology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2922287-81-6 |
| Applications | Polθ Inhibitor |
| Formula | C24H19F2N7O2S |
| Molecular Weight | 507.52 |
| SMILES | O=C(C1=C(C=C(N=C1)C2=NN(C=C2)C)C3=CC(C(F)F)=NC=C3OC)NC4=NN=C(S4)C#CC5CC5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.