Fig. 1 · Structure
Documents & Downloads
RP 67580
NK1 Receptors Antagonist, Substance P Antagonist
RP 67580 is a non-peptide antagonist targeting neurokinin receptor 1 (NK1) with a competitive inhibition mechanism for the binding of [3H]substance P (SP) in rat brain membranes, exhibiting a Ki value of 4.16 nM. This compound selectively inhibits NK1 receptors and serves as an essential tool in the study of pain mechanisms and neurogenic inflammation, facilitating research into potential therapeutic approaches for related conditions.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 135911-02-3 |
| Applications | NK1 Receptors Antagonist, Substance P Antagonist |
| Formula | C29H30N2O2 |
| Molecular Weight | 438.56 |
| SMILES | O=C1[C@@]2([H])CN(C(CC3=CC=CC=C3OC)=N)C[C@@]2([H])C(C4=CC=CC=C4)(C5=CC=CC=C5)CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.