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RP-69758

CCKB/Gastrin Receptor Antagonist

RP-69758 is a selective non-peptide antagonist of the cholecystokinin-B (CCKB)/gastrin receptor, demonstrating over 200-fold specificity for CCKB compared to CCKA receptors. This compound effectively inhibits CCK-8-induced neuronal firing in rat hippocampal slices and suppresses pentagastrin-induced gastric acid secretion in rats. RP-69758 serves as a valuable tool for investigating neurological disorders and gastrointestinal diseases in research applications.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	138562-23-9
Applications	CCKB/Gastrin Receptor Antagonist
Formula	C₂₆H₂₆N₄O₅
Molecular Weight	474.51
SMILES	O=C(CC1=CC=CC(NC(NCC(N(C2=CC=CC=C2)CC(N(C3=CC=CC=C3)C)=O)=O)=O)=C1)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.