Fig. 1 · Structure
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RP 72540
CCK-B Receptor Antagonist
RP 72540 is a selective antagonist of the CCK-B receptor, exhibiting IC50 values of 2.4 nM, 1.2 nM, and 3.8 nM in guinea pig, rat, and mouse cerebral cortices, respectively. This compound effectively inhibits CCK-8-induced neuronal firing and demonstrates a dose-dependent reduction in gastric acid secretion. RP 72540 serves as a valuable tool in research applications aiming to elucidate the physiological roles of CCK-B receptors, particularly in the context of gastrointestinal processes and neurophysiology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 139088-45-2 |
| Applications | CCK-B Receptor Antagonist |
| Formula | C28H30N4O6 |
| Molecular Weight | 518.56 |
| Synonyms | RPR101048 |
| SMILES | O=C(N(C1=CC=CC(OC)=C1)CC(N(C)C2=CC=CC=C2)=O)CNC(NC3=CC=CC(C(C(O)=O)C)=C3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.