RQ-00203078

Catalog No.: A15830

TRPM8 antagonist

RQ-00203078 Chemical Structure

CAS NO. 1254205-52-1

RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively), exhibits >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1.

Availability: In stock

Package Price Qty
10 mg
$120.00
25 mg
$250.00
50 mg
$450.00

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Biological Activity

RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively), exhibits >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.02 mL 90.11 mL 180.23 mL
0.5 mM 3.6 mL 18.02 mL 36.05 mL
1 mM 1.8 mL 9.01 mL 18.02 mL
5 mM 0.36 mL 1.8 mL 3.6 mL

*The above data is based on the productmolecular weight 554.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15830
Actions Antagonist
M. Wt 554.85
Formula C21H13ClF6N2O5S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1254205-52-1
Synonyms RQ 00203078, RQ00203078
SMILES ClC1=C(N(CC2=CC=C(OC(F)(F)F)C=C2)S(C3=CC=C(C(O)=O)C=C3)(=O)=O)N=CC(C(F)(F)F)=C1

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