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RU.521 (RU320521)

Catalog No.: A18811

cGAS inhibitor

RU.521 (RU320521)

RU.521 (RU320521) Chemical Structure

CAS NO. 2262452-06-0

RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation.

Availability: In stock

Package Price Qty
5 mg
$110.00
10 mg
$190.00
50 mg
$760.00
100 mg
$1,300.00
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Biological Activity

RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation.
In vitro DMSO 80 mg/mL (192.66 mM)
Water <1 mg/mL
Ethanol 2 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.08 mL 120.42 mL 240.83 mL
0.5 mM 4.82 mL 24.08 mL 48.17 mL
1 mM 2.41 mL 12.04 mL 24.08 mL
5 mM 0.48 mL 2.41 mL 4.82 mL

*The above data is based on the productmolecular weight 415.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18811
Actions Inhibitor
CAS No. 2262452-06-0
Formula C19H12Cl2N4O3
M. Wt 415.23
Purity >98%
Synonyms RU521, RU-521, RU-320521, RU 320521
SMILES O=C1OC(C2=C(O)N(C3=NC4=CC=C(Cl)C(Cl)=C4N3)N=C2C)C5=C1C=CC=C5
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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