Fig. 1 · Structure
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(S)-Donepezil
AChE Inhibitor
(S)-Donepezil is an S-enantiomer of Donepezil, serving as a specific and potent inhibitor of acetylcholinesterase (AChE). This compound enhances cholinergic neurotransmission by preventing the degradation of acetylcholine, making it a valuable tool in neuropharmacological research. It is primarily utilized in studies related to neurodegenerative diseases, particularly Alzheimer's disease, where modulation of AChE activity is of significant interest.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 142057-80-5 |
| Applications | AChE Inhibitor |
| Formula | C24H29NO3 |
| Molecular Weight | 379.49 |
| Synonyms | (S)-E2020 free base |
| SMILES | O=C1[C@@H](CC2CCN(CC3=CC=CC=C3)CC2)CC4=C1C=C(OC)C(OC)=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.