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Form	MW
(S)-Doxazosin This page	451.48
(R)-Doxazosin	451.48

(S)-Doxazosin

α1-adrenoceptor Antagonist

(S)-Doxazosin is a selective α1-adrenoceptor antagonist that exerts antihypertensive effects by reducing total peripheral resistance through selective postsynaptic α1-blockade. It has demonstrated efficacy in lowering blood pressure in canine models of experimentally induced renal hypertension. Additionally, (S)-Doxazosin can alleviate bladder outflow obstruction and may be relevant in research pertaining to mental health disorders. Its diverse applications make it a valuable reagent for cardiovascular and urological studies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	104874-86-4
Applications	α1-adrenoceptor Antagonist
Formula	C₂₃H₂₅N₅O₅
Molecular Weight	451.48
Synonyms	(S)-UK 33274
SMILES	O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)[C@H]4OC5=CC=CC=C5OC4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.