(S)-Mirtazapine is a stereoselective antagonist of the 5-HT2 receptor, showing significant pronociceptive effects in animal models of acute thermal nociception. This S(+)-enantiomer exhibits distinct pharmacological properties, contributing to its potential applications in pain research and neuropharmacology. Additionally, (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2, which may influence its therapeutic efficacy and safety profile.
(S)-Mirtazapine is a stereoselective antagonist of the 5-HT2 receptor, showing significant pronociceptive effects in animal models of acute thermal nociception. This S(+)-enantiomer exhibits distinct pharmacological properties, contributing to its potential applications in pain research and neuropharmacology. Additionally, (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2, which may influence its therapeutic efficacy and safety profile.
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