Fig. 1 · Structure
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(S)-OTS514
OTS514 Enantiomer
(S)-OTS514 is a selective inhibitor of T-lymphokine-activated killer cell-originated protein kinase (TOPK), exhibiting a potent inhibitory activity with an IC50 of 2.6 nM. This enantiomer effectively suppresses the proliferation of TOPK-positive cancer cells, leading to cell cycle arrest and the induction of apoptosis. (S)-OTS514 serves as a valuable tool for cancer research, particularly in studies focused on targeted therapies and cell signaling pathways involved in tumor growth.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1338541-25-5 |
| Applications | OTS514 Enantiomer |
| Formula | C21H20N2O2S |
| Molecular Weight | 364.46 |
| SMILES | O=C1NC2=C(C(C3=CC=C([C@H](C)CN)C=C3)=C(O)C=C2C)C4=C1SC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.