Fig. 1 · Structure
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(S)-Sitagliptin phosphate
Dipeptidyl Peptidase Inhibitor
(S)-Sitagliptin phosphate functions as a dipeptidyl peptidase 4 (DPP4) inhibitor, exhibiting a potent inhibitory effect with an IC50 of 19 nM in Caco-2 cell extracts. This compound demonstrates significant biological activity in the regulation of glucose metabolism and is primarily used in research focused on diabetes and metabolic disorders. Its potent inhibition of DPP4 makes it a valuable reagent for studies investigating therapeutic strategies to manage hyperglycemia and related conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 823817-58-9 |
| Applications | Dipeptidyl Peptidase Inhibitor |
| Formula | C16H18F6N5O5P |
| Molecular Weight | 505.31 |
| Synonyms | (S)-MK-0431 phosphate |
| SMILES | O=C(N1CC2=NN=C(C(F)(F)F)N2CC1)C[C@@H](N)CC3=CC(F)=C(F)C=C3F.O=P(O)(O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.