Fig. 1 · Structure
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S1QEL1.1
Complex I Inhibitor
S1QEL1.1 is a selective inhibitor of mitochondrial respiratory chain complex I, targeting the superoxide and hydrogen peroxide generation at the IQ site during reverse electron transfer, with an IC50 of 0.07 μM. This small molecule significantly mitigates the activation of caspases associated with endoplasmic reticulum stress. Additionally, S1QEL1.1 plays a crucial role in regulating stem cell proliferation by inhibiting the Reactive Oxygen Species signaling pathway activated by endoplasmic reticulum stress, making it a valuable tool for studying oxidative stress and mitochondrial function in various biological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 897613-29-5 |
| Applications | Complex I Inhibitor |
| Formula | C23H24N4O3S |
| Molecular Weight | 436.53 |
| SMILES | O=C(NC1=CC=CC(NC(C)=O)=C1)C(NCCC2=C(C)N=C(C3=CC=C(C)C=C3)S2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.