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S1R agonist 3

S1R Agonist

S1R Agonist 3 is a highly selective sigma-1 receptor (S1R) agonist with a binding affinity (Ki) of 1.5 nM. It demonstrates the capability to reduce hyperlocomotion in wfs1abKO zebrafish larvae while leaving locomotion unaltered in wildtype wfs1abWT zebrafish. Additionally, S1R Agonist 3 effectively reverses learning and memory deficits induced by the Aβ25-35 peptide, highlighting its potential utility in Alzheimer’s disease research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Agonist
CAS Number	401501-66-4
Applications	S1R Agonist
Formula	C₁₄H₂₀ClNO
Molecular Weight	253.77
SMILES	ClC1=CC=C(C=C1)OCCN2CCC(CC2)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.