S26131

Catalog No.: A61717
MT1 Antagonist
S26131 is a potent and selective antagonist of the MT1 melatonin receptor, exhibiting Ki values of 0.5 nM for MT1 and 112 nM for MT2. This compound's affinity and selectivity make it a valuable tool for studying melatonergic signaling pathways and their implications in various physiological and pathological processes. S26131 can be utilized in research exploring sleep regulation, circadian rhythms, and related neurobiological functions.
Grouped product items
Size Price Stock Qty
5mg
$30.00
In stock
10mg
$50.00
In stock
25mg
$100.00
In stock
50mg
$145.00
In stock
100mg
$210.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionS26131 is a potent and selective antagonist of the MT1 melatonin receptor, exhibiting Ki values of 0.5 nM for MT1 and 112 nM for MT2. This compound's affinity and selectivity make it a valuable tool for studying melatonergic signaling pathways and their implications in various physiological and pathological processes. S26131 can be utilized in research exploring sleep regulation, circadian rhythms, and related neurobiological functions.
Product Information
Catalog NumA61717
FormulaC31H34N2O4
Molecular Weight498.61
CAS Number296280-56-3
SMILESCC(NCCC1=C2C=C(C=CC2=CC=C1)OCCCOC3=CC=C4C=CC=C(C4=C3)CCNC(C)=O)=O
Useful Calculator

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