Fig. 1 · Structure
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Sabcomeline hydrochloride
Muscarinic Receptor Agonist
Sabcomeline hydrochloride is a muscarinic receptor agonist with the ability to penetrate the blood-brain barrier. It exhibits strong affinity for human muscarinic receptor subtypes hM1 to hM5 (pKi=6.72-7.23) and functions as a near-full agonist at the hM3 receptor, leading to extracellular acidification. This compound also influences dopamine D2 receptor binding kinetics via neural network modulation, while exhibiting minimal effects on cardiovascular parameters. Sabcomeline hydrochloride is valuable in research related to Alzheimer's disease and other neurodegenerative disorders, especially for investigating its effects on spatial memory and taste aversion in rodent models.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 159912-58-0 |
| Applications | Muscarinic Receptor Agonist |
| Formula | C10H16ClN3O |
| Molecular Weight | 229.71 |
| Synonyms | SB-202026 hydrochloride; Memric hydrochloride |
| SMILES | CO/N=C([C@@H]1C2CCN(CC2)C1)\C#N.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.